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A psychotherapist helps a law student cope with schizophrenia in one of five interconnected tales dealing with mental illness.

Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.

An unusual and wonderful friendship develops between a busy but unhappy salesman and a resident of a mental asylum.

Matthew, a young schizophrenic, finds himself out on the street when a slumlord tears down his apartment building. Soon, he finds himself in even more dire straits, when he is threatened by Little Leroy, a thug who is one of the tough denizens of the Fort Washington Shelter for Men. He reaches out to Jerry, a streetwise combat veteran, who takes Matthew under his wing as a son. The relationship between these two men grows as they attempt to conquer the numbing isolation of homelessness.

At the end of WWII, Jimmy Picard, a Native American Blackfoot who fought in France, suffers from unexplainable symptoms and is admitted to a military hospital. When doctors suspect schizophrenia, an eccentric psychoanalyst takes up the case and starts a conversation with the veteran.

The relationship of a couple who meet by chance in New York City is put to the test when they encounter a life or death circumstance.