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Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

Best pals CeCe and Rocky dream of dancing stardom. And they seem on the verge of realizing that goal when they win places as backup dancers on the local TV show "Shake It Up, Chicago." While they get to show off their moves, they find out they need to keep putting their best feet forward to keep up with the rest of the crew on the show.

When Shaggy's rich Uncle Albert goes missing and is presumed dead, Shaggy receives an inheritance, which he uses to upgrade the Mystery Machine so it can transform itself into other types of vehicles. Before disappearing, Uncle Albert made some enemies and it is up to Shaggy and his trusty canine, Scooby-Doo, to defeat those enemies, the most dangerous of whom is evil Dr. Phineas Phibes. Armed with the upgraded Mystery Machine, a loyal robot servant and their new riches, Shaggy and Scooby must stop Dr. Phibes' evil plans and save the world.